Etil Piruvatın Çeşitli Kanser Hücre Hatları Üzerindeki Sitotoksik Etkisinin İncelenmesi

Ethyl pyruvate (EP) is a simple aliphatic ester derived from pyruvic acid which an endogenous metabolite. Although various studies have investigated the antioxidant and anti-inflammatory properties of EP, there has been only limited research into cytotoxic effect EP on cancer cells. The aim this study was to determine effects cells representing common types. purchased commercially intermediate stock solutions were prepared with phosphate buffer saline. human melanoma (VMM917), cervix (HeLa), breast (MCF-7), lung (A549), liver (HepG2), colon (WiDr) normal fibroblast (BJ) determined using MTT assay. Cisplatin used as positive control in cytotoxicity experiments. results showed that exhibits selective VMM917 (10.1-fold) HeLa (3.04-fold) compared BJ This shows for first time highly effect, especially mechanism needs be elucidated by more extensive studies.